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Journal Article

Non-random genetic alterations in the cyanobacterium Nostoc sp. exposed to space conditions

Authors

Liu,  Yuguang
External Organizations;

Jeraldo,  Patricio
External Organizations;

Herbert,  William
External Organizations;

McDonough,  Samantha
External Organizations;

Eckloff,  Bruce
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de Vera,  Jean-Pierre
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Cockell,  Charles
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Leya,  Thomas
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Baqué,  Mickael
External Organizations;

Jen,  Jin
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/persons/resource/dirksm

Schulze-Makuch,  Dirk
3.7 Geomicrobiology, 3.0 Geochemistry, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum;

Walther-Antonio,  Marina
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Fulltext (public)

5013095.pdf
(Publisher version), 2MB

Supplementary Material (public)
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Citation

Liu, Y., Jeraldo, P., Herbert, W., McDonough, S., Eckloff, B., de Vera, J.-P., Cockell, C., Leya, T., Baqué, M., Jen, J., Schulze-Makuch, D., Walther-Antonio, M. (2022): Non-random genetic alterations in the cyanobacterium Nostoc sp. exposed to space conditions. - Scientific Reports, 12, 12580.
https://doi.org/10.1038/s41598-022-16789-w


Cite as: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5013095
Abstract
Understanding the impact of long-term exposure of microorganisms to space is critical in understanding how these exposures impact the evolution and adaptation of microbial life under space conditions. In this work we subjected Nostoc sp. CCCryo 231-06, a cyanobacterium capable of living under many different ecological conditions, and also surviving in extreme ones, to a 23-month stay at the International Space Station (the Biology and Mars Experiment, BIOMEX, on the EXPOSE-R2 platform) and returned it to Earth for single-cell genome analysis. We used microfluidic technology and single cell sequencing to identify the changes that occurred in the whole genome of single Nostoc cells. The variant profile showed that biofilm and photosystem associated loci were the most altered, with an increased variant rate of synonymous base pair substitutions. The cause(s) of these non-random alterations and their implications to the evolutionary potential of single bacterial cells under long-term cosmic exposure warrants further investigation.