Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Discovering Nature’s Fingerprints: Isotope Ratio Analysis on Bioanalytical Mass Spectrometers


Neubauer,  Cajetan
External Organizations;

Kantnerová,  Kristýna
External Organizations;

Lamothe,  Alexis
External Organizations;

Savarino,  Joel
External Organizations;

Hilkert,  Andreas
External Organizations;

Juchelka,  Dieter
External Organizations;

Hinrichs,  Kai-Uwe
External Organizations;

Elvert,  Marcus
External Organizations;

Heuer,  Verena
External Organizations;

Elsner,  Martin
External Organizations;

Bakkour,  Rani
External Organizations;


Julien,  Maxime
3.2 Organic Geochemistry, 3.0 Geochemistry, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum;

Öztoprak,  Merve
External Organizations;

Schouten,  Stefan
External Organizations;

Hattori,  Shohei
External Organizations;

Dittmar,  Thorsten
External Organizations;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in GFZpublic
Supplementary Material (public)
There is no public supplementary material available

Neubauer, C., Kantnerová, K., Lamothe, A., Savarino, J., Hilkert, A., Juchelka, D., Hinrichs, K.-U., Elvert, M., Heuer, V., Elsner, M., Bakkour, R., Julien, M., Öztoprak, M., Schouten, S., Hattori, S., Dittmar, T. (2023): Discovering Nature’s Fingerprints: Isotope Ratio Analysis on Bioanalytical Mass Spectrometers. - Journal of the American Society of Mass Spectrometry, 34, 4, 525-537.

Cite as: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5017508
For a generation or more, the mass spectrometry that developed at the frontier of molecular biology was worlds apart from isotope ratio mass spectrometry, a label-free approach done on optimized gas-source magnetic sector instruments. Recent studies show that electrospray-ionization Orbitraps and other mass spectrometers widely used in the life sciences can be fine-tuned for high-precision isotope ratio analysis. Since isotope patterns form everywhere in nature based on well-understood principles, intramolecular isotope measurements allow unique insights into a fascinating range of research topics. This Perspective introduces a wider readership to current topics in stable isotope research with the aim of discussing how soft-ionization mass spectrometry coupled with ultrahigh mass resolution can enable long-envisioned progress. We highlight novel prospects of observing isotopes in intact polar compounds and speculate on future directions of this adventure into the overlapping realms of biology, chemistry, and geology.