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  A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Cruces, P., Retamal, J., Hurtado, D. E., Erranz, B., Iturrieta, P. C., González, C., Díaz, F. (2020): A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection. - Critical Care, 24, 494.
https://doi.org/10.1186/s13054-020-03197-7

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Item Permalink: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5002959 Version Permalink: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5002959_2
Genre: Journal Article

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 Creators:
Cruces, Pablo1, Author
Retamal, Jaime1, Author
Hurtado, Daniel E.1, Author
Erranz, Benjamín1, Author
Iturrieta, Pablo Cristián2, Author              
González, Carlos1, Author
Díaz, Franco1, Author
Affiliations:
1External Organizations, ou_persistent22              
20 Pre-GFZ, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum, ou_146023              

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 Abstract: Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.

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Language(s): eng - English
 Dates: 2020-08-102020
 Publication Status: Finally published
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1186/s13054-020-03197-7
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Title: Critical Care
Source Genre: Journal, SCI, Scopus
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Pages: - Volume / Issue: 24 Sequence Number: 494 Start / End Page: - Identifier: CoNE: https://gfzpublic.gfz-potsdam.de/cone/journals/resource/202008211
Publisher: BioMed Central (BMC)