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Journal Article

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Authors

Cruces,  Pablo
External Organizations;

Retamal,  Jaime
External Organizations;

Hurtado,  Daniel E.
External Organizations;

Erranz,  Benjamín
External Organizations;

/persons/resource/pciturri

Iturrieta,  Pablo Cristián
0 Pre-GFZ, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum;

González,  Carlos
External Organizations;

Díaz,  Franco
External Organizations;

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Citation

Cruces, P., Retamal, J., Hurtado, D. E., Erranz, B., Iturrieta, P. C., González, C., Díaz, F. (2020): A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection. - Critical Care, 24, 494.
https://doi.org/10.1186/s13054-020-03197-7


Cite as: https://gfzpublic.gfz-potsdam.de/pubman/item/item_5002959
Abstract
Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.