The Pressure-Induced Polymorphic Transformations in Fluconazole

Gorkovenko, Ekaterina A.; Kichanov, Sergey E.; Kozlenko, Denis P.; Belushkin, Alexandr V.; Wąsicki, Jan; Nawrocik, Wojciech; Mielcarek, Jadwiga; Dubrovinsky, Leonid S.; Lathe, Christian; Savenko, Boris N.

doi:10.1002/jps.24644

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The Pressure-Induced Polymorphic Transformations in Fluconazole

Authors

Gorkovenko, Ekaterina A.
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Kichanov, Sergey E.
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Kozlenko, Denis P.
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Belushkin, Alexandr V.
External Organizations;

Wąsicki, Jan
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Nawrocik, Wojciech
External Organizations;

Mielcarek, Jadwiga
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Dubrovinsky, Leonid S.
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Lathe, Christian
CGS Centre for Geological Storage, Geoengineering Centres, GFZ Publication Database, Deutsches GeoForschungsZentrum;

Savenko, Boris N.
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Gorkovenko, E. A., Kichanov, S. E., Kozlenko, D. P., Belushkin, A. V., Wąsicki, J., Nawrocik, W., Mielcarek, J., Dubrovinsky, L. S., Lathe, C., Savenko, B. N. (2015): The Pressure-Induced Polymorphic Transformations in Fluconazole. - Journal of Pharmaceutical Sciences, 104, 12, 4164-4169.
https://doi.org/10.1002/jps.24644

Cite as: https://gfzpublic.gfz-potsdam.de/pubman/item/item_1342136

Abstract

The structural properties and Raman spectra of fluconazole have been studied by means of X-ray diffraction and Raman spectroscopy at pressures up to 2.5 and 5.5 GPa, respectively. At a pressure of 0.8 GPa, a polymorphic phase transition from the initial form I to a new triclinic form VIII has been observed. At higher pressure of P = 3.2 GPa, possible transformation into another new polymorphic form IX has been detected. The unit cell parameters and volumes, and vibration modes as functions of pressure have been obtained for the different forms of fluconazole. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.