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The Pressure-Induced Polymorphic Transformations in Fluconazole

Urheber*innen

Gorkovenko,  Ekaterina A.
External Organizations;

Kichanov,  Sergey E.
External Organizations;

Kozlenko,  Denis P.
External Organizations;

Belushkin,  Alexandr V.
External Organizations;

Wąsicki,  Jan
External Organizations;

Nawrocik,  Wojciech
External Organizations;

Mielcarek,  Jadwiga
External Organizations;

Dubrovinsky,  Leonid S.
External Organizations;

/persons/resource/lathe

Lathe,  Christian
CGS Centre for Geological Storage, Geoengineering Centres, GFZ Publication Database, Deutsches GeoForschungsZentrum;

Savenko,  Boris N.
External Organizations;

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Zitation

Gorkovenko, E. A., Kichanov, S. E., Kozlenko, D. P., Belushkin, A. V., Wąsicki, J., Nawrocik, W., Mielcarek, J., Dubrovinsky, L. S., Lathe, C., Savenko, B. N. (2015): The Pressure-Induced Polymorphic Transformations in Fluconazole. - Journal of Pharmaceutical Sciences, 104, 12, 4164-4169.
https://doi.org/10.1002/jps.24644


Zitierlink: https://gfzpublic.gfz-potsdam.de/pubman/item/item_1342136
Zusammenfassung
The structural properties and Raman spectra of fluconazole have been studied by means of X-ray diffraction and Raman spectroscopy at pressures up to 2.5 and 5.5 GPa, respectively. At a pressure of 0.8 GPa, a polymorphic phase transition from the initial form I to a new triclinic form VIII has been observed. At higher pressure of P = 3.2 GPa, possible transformation into another new polymorphic form IX has been detected. The unit cell parameters and volumes, and vibration modes as functions of pressure have been obtained for the different forms of fluconazole. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.